|
|
Malaria
|
What is malaria?
Malaria is a serious and sometimes fatal disease caused
by a parasite. Patients with malaria typically are very
sick with high fevers, shaking chills, and flu-like
illness. Four kinds of malaria parasites can infect
humans: Plasmodium falciparum, P. vivax, P. ovale, and
P. malariae.
Infection
with any of the malaria species can make a person feel
very ill; infection with P. falciparum, if not promptly
treated, may be fatal. Although malaria can be a fatal
disease, illness and death from malaria are largely
preventable.
|
Is malaria a common disease?
Yes.
The World Health Organization estimates that each year
300-500 million cases of malaria occur and more than
1 million people die of malaria.
|
Is malaria a serious disease?
Yes. Malaria is a leading cause of death and disease
worldwide, especially in developing countries. Most
deaths occur in young children. Since many countries
with malaria are already among the poorer nations, the
disease maintains a vicious cycle of disease and poverty.
|
Where does malaria occur?
Malaria
typically is found in warmer regions of the world --
in tropical and subtropical countries. Higher temperatures
allow the Anopheles mosquito to thrive. Malaria parasites,
which grow and develop inside the mosquito, need warmth
to complete their growth before they are mature enough
to be transmitted to humans. |
How is malaria transmitted?
Usually,
people get malaria by being bitten by an infected female
Anopheles mosquito. Only Anopheles mosquitoes can transmit
malaria and they must have been infected through a previous
blood meal taken on an infected person.
When a mosquito bites, a small amount of blood is taken
in which contains the microscopic malaria parasites.
The parasite grows and matures in the mosquito's gut
for a week or more, then travels to the mosquito's salivary
glands. When the mosquito next takes a blood meal, these
parasites mix with the saliva and are injected into
the bite.
Once in the blood, the parasites travel to the liver
and enter liver cells to grow and multiply. During this
"incubation period", the infected person has
no symptoms. After as few as 8 days or as long as several
months, the parasites leave the liver cells and enter
red blood cells. Once in the cells, they continue to
grow and multiply. After they mature, the infected red
blood cells rupture, freeing the parasites to attack
and enter other red blood cells. Toxins released when
the red cells burst are what cause the typical fever,
chills, and flu-like malaria symptoms.
If a mosquito bites this infected person and ingests
certain types of malaria parasites ("gametocytes"),
the cycle of transmission continues.
Because the malaria parasite is found in red blood cells,
malaria can also be transmitted through blood transfusion,
organ transplant, or the shared use of needles or syringes
contaminated with blood. Malaria may also be transmitted
from a mother to her fetus before or during delivery
("congenital" malaria).
Malaria is not transmitted from person to person like
a cold or the flu. You cannot get malaria from casual
contact with malaria-infected people.
|
Who
is at risk for malaria?
Anyone
can get malaria. Most cases occur in residents of countries
with malaria transmission and travelers to those countries.
In non-endemic countries, cases can occur in non-travelers
as congenital malaria, introduced malaria, or transfusion
malaria (see above).
|
If I live in an area where malaria is a problem,
how can I prevent myself and my family from getting
sick?
You
and your family can prevent malaria by
-
keeping mosquitoes from biting you, especially at
night.
- taking
antimalarial drugs to kill the parasites.
- eliminating
places around your home where mosquitoes breed.
- spraying
insecticides on your home's walls to kill adult
mosquitoes that come inside.
- sleeping
under bed nets - especially effective if they have
been treated with insecticide, and wearing insect
repellent and long-sleeved clothing if out of doors
at night.
|
What are the signs and symptoms of malaria?
Symptoms
of malaria include fever and flu-like illness, including
shaking chills, headache, muscle aches, and tiredness.
Nausea, vomiting, and diarrhea may also occur. Malaria
may cause anemia and jaundice (yellow coloring of the
skin and eyes) because of the loss of red blood cells.
Infection with one type of malaria, Plasmodium falciparum,
if not promptly treated, may cause kidney failure, seizures,
mental confusion, coma, and death.
|
How
soon will a person feel sick after being bitten by an
infected mosquito?
For
most people, symptoms begin 10 days to 4 weeks after
infection, although a person may feel ill as early as
7 days or as late as 1 year later. Two kinds of malaria,
P. vivax and P. ovale, can relapse. In P. vivax and
P. ovale infections, some parasites can remain dormant
in the liver for several months up to about 4 years
after a person is bitten by an infected mosquito. When
these parasites come out of hibernation and begin invading
red blood cells ("relapse"), the person will
become sick.
|
How
do I know if I have malaria?
Most
people, at the beginning of the disease, have fever,
sweats, chills, headaches, malaise, muscles aches, nausea
and vomiting. Malaria can very rapidly become a severe
and life-threatening disease. The surest way for you
and your doctor to know whether you have malaria is
to have a diagnostic test where a drop of your blood
is examined under the microscope for the presence of
malaria parasites.
If you are sick and there is any suspicion of malaria
(for example, if you have recently traveled in a malaria-risk
area) the test should be performed without delay.
|
|
|
|
|
Dengue
(pronounced den' gee) is a disease caused by any
one of four closely related viruses (DEN-1, DEN-2,
DEN-3, or DEN-4). The viruses are transmitted
to humans by the bite of an infected mosquito.
In the Western Hemisphere, the Aedes aegypti mosquito
is the most important transmitter or vector of
dengue viruses.
|
What is dengue haemorrhagic fever (DHF)?
DHF
is a more severe form of dengue. It can be fatal
if unrecognised and not properly treated. DHF
is caused by infection with the same viruses that
cause dengue. With good medical management, mortality
due to DHF can be less than 1%. |
How are dengue and dengue hemorrhagic
fever (DHF) spread?
Dengue
is transmitted to people by the bite of an Aedes
mosquito that is infected with a dengue virus.
The mosquito becomes infected with dengue virus
when it bites a person who has dengue or DHF and
after about a week can transmit the virus while
biting a healthy person. Dengue cannot be spread
directly from person to person. |
What are the symptoms of the disease?
The
principal symptoms of dengue are high fever, severe
headache, backache, joint pains, nausea and vomiting,
eye pain, and rash. Generally, younger children
have a milder illness than older children and
adults.
Dengue hemorrhagic fever is characterized by a
fever that lasts from 2 to 7 days, with general
signs and symptoms that could occur with many
other illnesses (e.g., nausea, vomiting, abdominal
pain, and headache). This stage is followed by
hemorrhagic manifestations, tendency to bruise
easily or other types of skin haemorrhages, bleeding
nose or gums, and possibly internal bleeding.
The smallest blood vessels (capillaries) become
excessively permeable ("leaky"), allowing
the fluid component to escape from the blood vessels.
This may lead to failure of the circulatory system
and shock, followed by death, if circulatory failure
is not corrected. |
What is the treatment for dengue?
There
is no specific medication for treatment of a dengue
infection. Persons who think they have dengue
should use analgesics (pain relievers) with acetaminophen
and avoid those containing aspirin. They should
also rest, drink plenty of fluids, and consult
a physician. |
Is
there an effective treatment for dengue hemorrhagic
fever (DHF)?
As
with dengue, there is no specific medication for
DHF. It can however be effectively treated by
fluid replacement therapy if an early clinical
diagnosis is made. Hospitalisation is frequently
required in order to adequately manage DHF. |
What
can be done to reduce the risk of acquiring dengue?
There
is no vaccine for preventing dengue. The best
preventive measure for residents living in areas
infested with Aedes aegypti is to eliminate the
places where the mosquito lays her eggs, primarily
artificial containers that hold water.
Items that collect rainwater or are used to store
water (for example, plastic containers, big drums,
buckets, or used automobile tires) should be covered
or properly discarded. Pet and animal watering
containers and vases with fresh flowers should
be emptied and scoured at least once a week. This
will eliminate the mosquito eggs and larvae and
reduce the number of mosquitoes present in these
areas.
|
- Tests
for Dengue.
-
CBC - WBC Count, Platelet Count, Haematocrit.
-
S. Protien, S. Albumin.
-
Liver Function Tests.
-
Urine - microscopic haematuria.
-
Dengue IgG & IgM.
|
The
tests for diagnosis of dengue infection are time
dependent.
If the patient presents within the first 5 days
after onset of symptoms, which is the acute phase
of the illness, a blood sample should be drawn
immediately, to be tested for virus isolation.
Virus can be isolated most easily in samples drawn
in the first days after onset of symptoms, although
it has been isolated as long as 12 days after
onset.
A convalescent-phase sample should also be drawn
to test for IgM antibody. This sample should be
drawn between 6 and 21 days after symptom onset.
If the patient presents six or more days after
symptom onset, the blood sample should be drawn
as soon as possible. This sample should then be
tested for serum IgM antibody. |
| |
|
Diabetes
Diabetes
is a disease in which the body does not
produce or properly use insulin. Insulin
is a hormone that is needed to convert sugar,
starches and other food into energy needed
for daily life. The cause of diabetes continues
to be a mystery, although both genetics
and environmental factors such as obesity
and lack of exercise appear to play roles.
In
order to determine whether or not a patient
has pre-diabetes or diabetes, we conduct
a Fasting Blood Glucose Test (FBG) or an
Oral Glucose Tolerance Test (OGTT). Either
test can be used to diagnose pre-diabetes
or diabetes. The American Diabetes Association
recommends the FPG because it is easier,
faster, and less expensive to perform.
With
the FPG test, a fasting blood glucose level
between 100 and 125 mg/dl signals pre-diabetes.
A person with a fasting blood glucose level
of 126 mg/dl or higher has diabetes.
In
the OGTT test, a person's blood glucose
level is measured after a fast and two hours
after drinking a glucose-rich beverage.
If the two-hour blood glucose level is between
140 and 199 mg/dl, the person tested has
pre-diabetes. If the two-hour blood glucose
level is at 200 mg/dl or higher, the person
tested has diabetes.
|
Major Types of Diabetes |
-
Type
1 Diabetes : Type 1 diabetes
is usually diagnosed in children and
young adults, and was previously known
as juvenile diabetes. In type 1diabetes,
the body does not produce insulin.
-
Type
2 Diabetes : Type 2 diabetes
is the most common form of diabetes.
In type 2 diabetes, either the body
does not produce enough insulin or the
cells ignore the insulin. When glucose
builds up in the blood instead of going
into cells, it can cause two problems:
* Right away, your cells may be starved
for energy.
* Over time, high blood glucose levels
may hurt your eyes, kidneys, nerves
or heart.
Finding out you have diabetes is scary.
But don't panic. Having diabetes is
serious, but people with diabetes can
live long, healthy, happy lives.
-
Gestational Diabetes :
Pregnant women who have never had diabetes
before but who have high blood sugar
(glucose) levels during pregnancy are
said to have gestational diabetes.
Gestational
diabetes starts when your body is not
able to make and use all the insulin
it needs for pregnancy. Without enough
insulin, glucose cannot leave the blood
and be changed to energy. Glucose builds
up in the blood to high levels. This
is called hyperglycemia.
-
Pre Diabetes : Before
people develop type 2 diabetes, they
almost always have "pre-diabetes"
-- blood glucose levels that are higher
than normal but not yet high enough
to be diagnosed as diabetes. Recent
research has shown that some long-term
damage to the body, especially the heart
and circulatory system, may already
be occurring during pre-diabetes.
Research
has also shown that if you take action
to manage your blood glucose when you
have pre-diabetes, you can delay or
prevent type 2 diabetes from ever developing.
|
How to Tell if You Have Pre-Diabetes
While diabetes and pre-diabetes occur in
people of all ages and races, some groups
have a higher risk for developing the disease
than others. There are two different tests
your doctor can use to determine whether
you have pre-diabetes: the fasting blood
glucose test (FPG) or the oral glucose tolerance
test (OGTT). The blood glucose levels measured
after these tests determine whether you
have a normal metabolism, or whether you
have pre-diabetes or diabetes. If your blood
glucose level is abnormal following the
FPG, you have impaired fasting glucose (IFG);
if your blood glucose level is abnormal
following the OGTT, you have impaired glucose
tolerance (IGT).
|
Does Someone You Know Have Pre-diabetes?
Mr. Shah, 48, was getting dangerously close
to a diagnosis of type 2 diabetes. A fasting
blood glucose done by his doctor was 111
mg/dl, and a week later it was 115 mg/dl.
Normal fasting blood glucose is under 100
mg/dl; diabetes is diagnosed when the fasting
blood glucose is 126 mg/dl or higher. A
fasting blood glucose between 100 mg/dl
and 125 mg/dl is called impaired fasting
glucose (IFG).
His
doctor sent Mr. Shah for a glucose tolerance
check. Mr. Shah drank a set amount of glucose;
his blood glucose two hours later was 173mg/dl.
Normal is under 140mg/dl, diabetes is 200
mg/dl or over. Mr. Shah had impaired glucose
tolerance (IGT).
Because
so many people with IFG or IGT go on to
develop diabetes, IFG and IGT are called
pre-diabetes.
Would
Mr. Shah be one of those who gets worse
and develops diabetes? Or would he be able
to shift his blood glucose back to solidly
non- diabetic levels?
Pre-diabetes
was not Mr. Shah's only problem. He had
been treated for high blood pressure for
eight years. He was overweight, and he had
gained 20 pounds in the last year. He was
not physically active. He didn't have healthy
cholesterol levels. He had a family history
of type 2 diabetes and coronary artery disease.
All of these taken together meant that Mr.
Shah was at high risk of developing type
2 diabetes and having heart problems in
the future. |
Reversible
Many people with pre-diabetes are able to
change their fates by losing a little weight
(just 10 or 20 pounds can make a difference)
and walking 150 minutes a week. Losing a
little weight and being more active also
improves blood pressure and cholesterol
levels and lowers the risk of heart attack
and stroke.
Mr. Shah met with a dietitian for help in
losing weight. He had a treadmill stress
test to see whether his heart could tolerate
an exercise program. He was advised to do
30 minutes of brisk walking five days per
week.
Six months later, Mr. Shah returned for
a check-up. He had gained seven pounds.
He was exercising only 20 minutes per week.
His fasting blood glucose had increased
to 117 mg/dl.
|
What You Can Do
First, calculate your body mass index (BMI):
Take your weight in pounds, divide by height
in inches, divide by height again, then
multiply by 703.
|
Have your blood glucose levels checked
if you are: |
-
Age
45 or older, especially if your BMI
is 25 or higher
-
Under
age 45 but your BMI is 25 or higher
plus you have another risk factor for
type 2 diabetes: high blood pressure,
history of gestational diabetes, a baby
weighing more than nine pounds at birth,
polycystic ovary syndrome, HDL (good)
cholesterol under 35 mg/dl, triglycerides
over 250 mg/dl, first-degree relative
with diabetes, history of vascular disease,
or habitual inactivity.
|
Get rechecked every three years |
If blood tests determine that you have pre-diabetes:
|
|
|
|
|
What
Is Cholesterol?
To
understand high blood cholesterol,
it is important to know more about
cholesterol.
Cholesterol is a waxy, fat-like
substance that is found in all cells
of the body. Your body needs some
cholesterol to work the right way
and makes all the cholesterol you
need.
Cholesterol is also found in some
of the foods you eat.
You
use cholesterol to make hormones,
Vitamin D, and substances that help
you digest foods.
Blood
is watery and cholesterol is fatty.
Just like oil and water, the two
do not mix. So, in order to travel
in the bloodstream, cholesterol
is carried in small packages called
lipoproteins (lip-o-PRO-teens).
The small packages are made of fat
(lipid) on the inside and proteins
on the outside. Two kinds of lipoproteins
carry cholesterol throughout your
body. It is important to have healthy
levels of both:
|
LDL
(low density lipoprotein) cholesterol
is sometimes called "bad"
cholesterol.
High LDL cholesterol leads to a
buildup of cholesterol in arteries.
The higher the LDL level in your
blood, the greater chance you have
for getting heart disease.
|
HDL
(high density lipoprotein)
cholesterol is sometimes called
"good" cholesterol.
HDL carries cholesterol from other
parts of your body back to your
liver. The liver removes the cholesterol
from your body. The higher your
HDL cholesterol level, the lower
your chance of getting heart disease.
|
What is a lipid profile?
The
lipid profile is a group of tests
that are often ordered together
to determine risk of coronary heart
disease. The tests that make up
a lipid profile are tests that have
been shown to be good indicators
of whether someone is likely to
have a heart attack or stroke caused
by blockage of blood vessels (hardening
of the arteries)
|
What tests are included
in a lipid profile?
The
lipid profile includes total cholesterol,
HDL-cholesterol (often called good
cholesterol), LDL-cholesterol (often
called bad cholesterol), and triglycerides.
Sometimes
the report will include additional
calculated values such as HDL/Cholesterol
ratio or a risk score based on lipid
profile results, age, sex, and other
risk factors. |
How is a lipid profile used?
The
lipid profile is used to guide physicians
in deciding how a person at risk
should be treated. The results of
the lipid profile are considered
along with other known risk factors
of heart disease to develop a plan
of treatment and follow-up. |
What Is High Blood Cholesterol?
Too
much cholesterol (ko-LES-ter-ol)
in the blood, or high blood cholesterol,
can be serious. People with high
blood cholesterol have a greater
chance of getting heart disease.
High blood cholesterol itself does
not cause symptoms, so many people
are unaware that their cholesterol
level is too high.
Other Names for High Blood Cholesterol
-
Hypercholesterolemia
- Hyperlipidemia.
|
What Causes High Blood Cholesterol?
A variety of things can affect the
cholesterol levels in your blood.
Some of these things you can control
and others you cannot.
|
You can control:
What you eat. Certain foods have
types of fat that raise your cholesterol
level.
Saturated fat raises your LDL cholesterol
level more than anything else in
your diet.
Trans fatty acids (trans fats) are
made when vegetable oil is "hydrogenated"
to harden it. Trans fatty acids
also raise cholesterol levels.
Cholesterol is found in foods that
come from animal sources, for example,
egg yolks, meat, and cheese.
Your
weight : Being overweight
tends to increase your LDL level,
lower your HDL level, and increase
your total cholesterol level.
Your activity :
Lack of regular exercise can lead
to weight gain and raise your LDL
cholesterol level. Regular exercise
can help you lose weight and lower
your LDL level. It can also help
you raise your HDL level.
You cannot control : Heredity.
High blood cholesterol can run in
families. An inherited genetic condition
(familial hypercholesterolemia)
results in very high LDL cholesterol
levels. It begins at birth, and
results in a heart attack at an
early age.
Age and sex Starting at puberty,
men have lower levels of HDL than
women. As women and men get older,
their LDL cholesterol levels rise.
Younger women have lower LDL cholesterol
levels than men, but after age 55
they have higher levels than men.
|
What
Are the Signs and Symptoms of High
Blood Cholesterol?
There are usually no signs or symptoms
of high blood cholesterol. Many
people don't know that their cholesterol
level is too high.
Everyone
age 20 and older should have their
cholesterol levels checked at least
once every 5 years. You and your
doctor can discuss how often you
should be tested. |
How is High Blood Cholesterol
Diagnosed?
High blood cholesterol is diagnosed
by checking levels of cholesterol
in your blood. It is best to have
a blood test called a lipid profile
to measure your cholesterol levels.
Most people will need to "fast"
(not eat or drink anything) for
9 to 12 hours before taking the
test.
The
lipoprotein profile will give information
about your:
|
- Total
cholesterol.
- LDL
(bad) cholesterol: the main
source of cholesterol buildup
and blockage in the arteries.
- HDL
(good) cholesterol: the good
cholesterol that helps keep
cholesterol from building up
in arteries.
- Triglycerides:
another form of fat in your
blood.
|
If
it is not possible to get a lipid
profile done, knowing your total
cholesterol and HDL cholesterol
can give you a general idea about
your cholesterol levels. Testing
for total and HDL cholesterol does
not require fasting. If your total
cholesterol is 200 mg/dL or more,
or if your HDL is less than 40 mg/dL,
you will need to have a lipoprotein
profile done. |
|
|
Leptospirosis
What
is leptospirosis?
Leptospirosis is a bacterial disease
that affects humans and animals.
It is caused by bacteria of the
genus Leptospira.
In
humans it causes a wide range of
symptoms, and some infected persons
may have no symptoms at all.
Symptoms
of leptospirosis include high fever,
severe headache, chills, muscle
aches, and vomiting, and may include
jaundice (yellow skin and eyes),
red eyes, abdominal pain, diarrhea,
or a rash. If the disease is not
treated, the patient could develop
kidney damage, meningitis (inflammation
of the membrane around the brain
and spinal cord), liver failure,
and respiratory distress. In rare
cases death occurs.
Many
of these symptoms can be mistaken
for other diseases. Leptospirosis
is confirmed by laboratory testing
of a blood or urine sample.
|
How do people get leptospirosis?
Outbreaks of leptospirosis are usually
caused by exposure to water contaminated
with the urine of infected animals.
Many different kinds of animals
carry the bacterium; they may become
sick but sometimes have no symptoms.
Leptospira
organisms have been found in cattle,
pigs, horses, dogs, rodents, and
wild animals. Humans become infected
through contact with water, food,
or soil containing urine from these
infected animals. This may happen
by swallowing contaminated food
or water or through skin contact,
especially with mucosal surfaces,
such as the eyes or nose, or with
broken skin.
The
disease is not known to be spread
from person to person. |
How long is it between the
time of exposure and when people
become sick?
The time between a person's exposure
to a contaminated source and becoming
sick is 2 days to 4 weeks. Illness
usually begins abruptly with fever
and other symptoms.
Leptospirosis
may occur in two phases; after the
first phase, with fever, chills,
headache, muscle aches, vomiting,
or diarrhea, the patient may recover
for a time but become ill again.
If a second phase occurs, it is
more severe; the person may have
kidney or liver failure or meningitis.
This phase is also called Weil's
disease.
The illness lasts from a few days
to 3 weeks or longer. Without treatment,
recovery may take several months. |
Where is leptospirosis found?
Leptospirosis occurs worldwide but
is most common in temperate or tropical
climates. It is an occupational
hazard for many people who work
outdoors or with animals, for example,
farmers, sewer workers, veterinarians,
fish workers, dairy farmers, or
military personnel. It is a recreational
hazard for campers or those who
participate in outdoor sports in
contaminated areas and has been
associated with swimming, wading,
and whitewater rafting in contaminated
lakes and rivers. The incidence
is also increasing among urban children.
How is leptospirosis treated?
Leptospirosis is treated with antibiotics,
such as doxycycline or penicillin,
which should be given early in the
course of the disease. Intravenous
antibiotics may be required for
persons with more severe symptoms.
Persons
with symptoms suggestive of leptospirosis
should contact a physician. |
Can leptospirosis be prevented?
The risk of acquiring leptospirosis
can be greatly reduced by not swimming
or wading in water that might be
contaminated with animal urine.
Protective
clothing or footwear should be worn
by those exposed to contaminated
water or soil because of their job
or recreational activities.
Tests for Leptospirosis
|
-
Complete Blood Count
- Urinalysis
- Creatinine
- Dark
Ground Illumination
- Leptospirosis
IgM Spot Test
|
|
|
Tuberculosis
What is Tuberculosis (TB)?
Tuberculosis (TB) is a disease caused by
bacteria called Mycobacterium tuberculosis.
The bacteria usually attack the lungs. But,
TB bacteria can attack any part of the body
such as the kidney, spine, and brain. If
not treated properly, TB disease can be
fatal.
TB is spread through the air from one person
to another. The bacteria are put into the
air when a person with active TB disease
of the lungs or throat coughs or sneezes.
People nearby may breathe in these bacteria
and become infected.
However, not everyone infected with TB bacteria
becomes sick.
People who are not sick have what is called
latent TB infection. People who have latent
TB infection do not feel sick, do not have
any symptoms, and cannot spread TB to others.
But, some people with latent TB infection
go on to get TB disease.
People with active TB disease can be treated
and cured if they seek medical help. Even
better, people with latent TB infection
can take medicine so that they will not
develop active TB disease. |
How is TB spread?
TB is spread through the air from one person
to another. The bacteria are put into the
air when a person with active TB disease
of the lungs or throat coughs or sneezes.
People nearby may breathe in these bacteria
and become infected.
When a person breathes in TB bacteria, the
bacteria can settle in the lungs and begin
to grow. From there, they can move through
the blood to other parts of the body, such
as the kidney, spine, and brain.
TB in the lungs or throat can be infectious.
This means that the bacteria can be spread
to other people. TB in other parts of the
body, such as the kidney or spine, is usually
not infectious.
People with active TB disease are most likely
to spread it to people they spend time with
every day. This includes family members,
friends, and coworkers.
|
What is latent TB infection?
In most people who breathe in TB bacteria
and become infected, the body is able to
fight the bacteria to stop them from growing.
The bacteria become inactive, but they remain
alive in the body and can become active
later. This is called latent TB infection.
People with latent TB infection
|
-
have no symptoms
-
don't feel sick
-
can't spread TB to others
-
usually have a positive skin test reaction
-
can develop active TB disease if they
do not receive treatment for latent
TB infection
|
Many people who have latent TB infection
never develop active TB disease. In these
people, the TB bacteria remain inactive
for a lifetime without causing disease.
But in other people, especially people who
have weak immune systems, the bacteria become
active and cause TB disease.
|
What is active TB disease?
TB
bacteria become active if the immune system
can't stop them from growing. The active
bacteria begin to multiply in the body and
cause active TB disease. The bacteria attack
the body and destroy tissue. If this occurs
in the lungs, the bacteria can actually
create a hole in the lung. Some people develop
active TB disease soon after becoming infected,
before their immune system can fight the
TB bacteria. Other people may get sick later,
when their immune system becomes weak for
another reason.
Babies and young children often have weak
immune systems. People infected with HIV,
the virus that causes AIDS, have very weak
immune systems. Other people can have weak
immune systems, too, especially people with
any of these conditions: |
- substance
abuse
-
diabetes mellitus
-
silicosis
-
cancer of the head or neck
-
leukemia or Hodgkin's disease
-
severe kidney disease
-
low body weight
- certain
medical treatments (such as corticosteroid
treatment or organ transplants)
- specialized
treatment for rheumatoid arthritis or
Crohn's disease
|
Symptoms of TB depend on where in
the body the TB bacteria are growing. TB
bacteria usually grow in the lungs. TB in
the lungs may cause symptoms such as
|
- a
bad cough that lasts 3 weeks or longer
- pain
in the chest
- coughing
up blood or sputum (phlegm from deep
inside the lungs)
|
Other
symptoms of active TB disease are |
- weakness
or fatigue
- weight
loss
- no
appetite
- chills
- fever
- sweating
at night
|
The TB skin test
The TB skin test may be used to find out if
you have TB infection. You can get a skin
test at any pathology laboratory. A technician
will inject a small amount of testing fluid
(called tuberculin or PPD) just under the
skin on the under side of the forearm. After
48 hours, you must return to have your skin
test read by the laboratory technician. You
may have a swelling where the tuberculin was
injected. The technician will measure this
swelling and tell you if your reaction to
the test is positive or negative. A positive
reaction usually means that you have been
infected by someone with active TB disease.
If you have recently spent time with and been
exposed to someone with active TB disease,
your TB skin test reaction may not be positive
yet. You may need a second skin test 8 to
10 weeks after the last time you spent time
with the person. This is because it can take
several weeks after infection for your immune
system to react to the TB skin test. If your
reaction to the second test is negative, you
probably do not have latent TB infection.
QuantiFERON®-TB Gold
QuantiFERON®-TB Gold (QFT) is a blood
test used to find out if you are infected
with TB bacteria. The QFT measures the response
to TB proteins when they are mixed with a
small amount of blood. Currently, few labs
offer the QFT. If your laboratory does offer
the QFT, only one visit is required, at which
time your blood is drawn for the test. |
What if I have a positive test for
TB?
If you have a positive reaction to the TB
skin test or the QFT, your doctor may do other
tests to see if you have active TB disease.
These tests usually include a chest x-ray
and a test of the phlegm you cough up. Because
the TB bacteria may be found somewhere other
than your lungs, your doctor may check your
blood or urine, or do other tests. If you
have active TB disease, you will need to take
medicine to cure the disease.
Tuberculosis (TB)
Profile
|
- Complete
Blood Count
- ESR
- Adenosine
Deaminase
- Mantoux
Test
- Chest
X Ray
- Sputum
AFB
|
|
|
Arthritis
While often referred to as if it
were a single disease, arthritis is actually
an umbrella term used for a group of more
than 100 medical conditions that collectively
affect nearly 70 million adults and 300,000
children in America alone.
While
the most common form of arthritis - osteoarthritis
- is most prevalent in people over 60, arthritis
in its various forms can start as early
as infancy. Some forms affect people in
their young-adult years as they are beginning
careers and families and still others start
during the peak career and child-rearing
years.
The common thread among these 100-plus conditions
is that they all affect the musculoskeletal
system and specifically the joints - where
two or more bones meet.
Arthritis-related joint problems include
pain, stiffness, inflammation and damage
to joint cartilage (the tough, smooth tissue
that covers the ends of the bones, enabling
them to glide against one another) and surrounding
structures. Such damage can lead to joint
weakness, instability and visible deformities
that, depending on the location of joint
involvement, can interfere with the most
basic daily tasks such as walking, climbing
stairs, using a computer keyboard, cutting
your food or brushing your teeth.
For many people with arthritis, however,
joint involvement is not the extent of the
problem. Many forms of arthritis are classified
as systemic, meaning they can affect the
whole body. In these diseases, arthritis
can cause damage to virtually any bodily
organ or system, including the heart, lungs,
kidneys, blood vessels and skin. Arthritis-related
conditions primarily affect the muscles
and the bones.
|
|
Arthritis
causes pain, loss of movement and sometimes
swelling. Some types of arthritis are: |
- Osteoarthritis,
a degenerative joint disease in which
the cartilage that covers the ends of
bones in the joint deteriorates, causing
pain and loss of movement as bone begins
to rub against bone. It is the most
prevalent form of arthritis.
- Rheumatoid
arthritis, an autoimmune disease in
which the joint lining becomes inflamed
as part of the body's immune system
activity. Rheumatoid arthritis is one
of the most serious and disabling types,
affecting mostly women.
- Gout,
which affects mostly men. It is usually
the result of a defect in body chemistry.
This painful condition most often attacks
small joints, especially the big toe.
Fortunately, gout almost always can
be completely controlled with medication
and changes in diet.
- Ankylosing
spondylitis, a type of arthritis that
affects the spine. As a result of inflammation,
the bones of the spine grow together.
- Juvenile
arthritis, a general term for all types
of arthritis that occur in children.
Children may develop juvenile rheumatoid
arthritis or childhood forms of lupus,
ankylosing spondylitis or other types
of arthritis.
- Systemic
lupus erythematosus (lupus), a serious
disorder that can inflame and damage
joints and other connective tissues
throughout the body.
- Scleroderma,
a disease of the body's connective tissue
that causes a thickening and hardening
of the skin.
|
Fibromyalgia, in which widespread pain affects
the muscles and attachments to the bone.
It affects mostly women.
Arthritis Profile
|
- Complete Blood Count
- ESR
- R A Factor
- Uric Acid
- C Reactive Protein
(Quantitative)
- Anti Nuclear Antibody
- Creatinine
- Urinalysis
|
|
|
Anaemia
Anemia is a serious condition that can make
a person feel tired and weak and can lead
to serious heart problems and other health
complications.
The good news is anemia can be treated and
people may regain their independence and
go on to live healthier, more productive
lives.
The blood in our bodies is composed of three
types of cells (red blood cells, white blood
cells and platelets) that circulate throughout
the body.
Red blood cells contain hemoglobin (Hb),
a red, iron-rich protein that carries oxygen
from the lungs to all of the body's muscles
and organs. Oxygen provides the energy the
body needs for all of its normal activities.
Anemia occurs when the number of red blood
cells (or the Hb in them) falls below normal
and the body gets less oxygen and therefore
has less energy than it needs to function
properly.
Anemia may become worse if it is not treated,
and it can lead to potentially serious,
even life-threatening complications. When
the number of red blood cells decreases,
the heart works harder, pumping more blood
to send more oxygen throughout the body.
If the heart works too hard, it can develop
a rapid heartbeat (tachycardia), and/or
another serious condition known as left
ventricular hypertrophy (LVH), an enlargement
of the heart muscle that in turn can lead
to heart failure. |
What causes Anaemia?
Anemia
occurs when the body produces too few red
blood cells, loses too many of them, or
if red blood cells are destroyed faster
than they can be replaced.
There
are close to 100 different types of anemia
with many causes, including: |
- Serious
disease
- Vitamin
or iron deficiencies
- Blood
loss
- Genetic
or acquired defects or disease
- Side
effects of medication
|
Who
is at risk?
Evidence shows that people who suffer from
the following serious diseases are at greatest
risk of developing anemia: |
-
Chronic Kidney Disease (CKD)
- Diabetes
- Cancer
- Heart
Disease
- Rheumatoid
Arthritis (RA)
- Inflammatory
Bowel Disease (IBD)
|
Also
at risk are: |
- People
over the age of 65
- People
with HIV/AIDS
-
Patients undergoing surgery
- Signs
and Symptoms
|
Anemia can be difficult to identify because
early symptoms may be mild. In addition,
it is easy to mistake some symptoms of anemia
for symptoms of serious disease or medication
side effects. As symptoms of anemia worsen,
however, they can significantly affect a
person's quality of life.
It is common for people to ignore symptoms
of anaemia or attribute them to other causes.
Anemia can make it hard to find the energy
to enjoy hobbies or other leisure activities,
or even to complete basic tasks at home
or at work. Particularly for a person with
a serious disease, the fatigue, weakness
and other symptoms associated with anemia
can compound the challenges of coping with
the serious disease.
Major symptoms of anemia include:
|
- Extreme
fatigue
- Weakness
- Shortness
of breath
- Confusion
or loss of concentration
- Dizziness
or fainting
- Pale
skin, including decreased pinkness of
the lips, gums, lining of the eyelids,
nail beds and palms
- Rapid
heart beat (tachycardia)
- Feeling
cold
- Sadness
or depression
|
Because
the symptoms of anemia are easily confused
with the symptoms of other conditions, it
is important to see a doctor for an evaluation
if you are experiencing significant fatigue
or other signs and symptoms listed above,
or if you already have a serious disease.
Diagnosing Anaemia
Doctors
diagnose anemia with the help of a medical
history, physical exam and blood tests,
including a complete blood count (CBC) to
measure levels of red blood cells and hemoglobin
in the blood.
On
average, a normal hemoglobin range should
be between 12 and 18 g/dL (grams per deciliter
of blood).
Anemia occurs when the number of red blood
cells (or the hemoglobin in them) falls
below these normal ranges and the body's
organs and tissues receive less oxygen than
needed to function properly. Although "normal"
is something that varies from person to
person, if your numbers are below the ranges,
then you may be feeling worse than you should. |
Treating Anaemia
The
treatment of anemia varies greatly depending
on the type. Your physician will help you
determine the best treatment options, such
as diet modification, or nutritional supplements,
or medication, if needed.
Treatment for anemia associated with serious
diseases tends to focus first on addressing
the underlying disease. But if anemia persists
or symptoms worsen, treatment may reduce
the risk of severe, possibly life-threatening
complications and improve quality of life.
Anaemia
Profile |
- Complete
Blood Count
- Iron
- Total
Iron Binding Capacity (TIBC)
- Iron
Saturation
- Ferritin
- Reticulocyte
Count
|
Do
you need to be screened for anaemia?
Call
+91 288 2770646 or write to info@shreylab.com
for more details. |
|
|
|
|
|