Malaria


What is malaria?


Malaria is a serious and sometimes fatal disease caused by a parasite. Patients with malaria typically are very sick with high fevers, shaking chills, and flu-like illness. Four kinds of malaria parasites can infect humans: Plasmodium falciparum, P. vivax, P. ovale, and P. malariae.

Infection with any of the malaria species can make a person feel very ill; infection with P. falciparum, if not promptly treated, may be fatal. Although malaria can be a fatal disease, illness and death from malaria are largely preventable.


Is malaria a common disease?

Yes. The World Health Organization estimates that each year 300-500 million cases of malaria occur and more than 1 million people die of malaria.


Is malaria a serious disease?


Yes. Malaria is a leading cause of death and disease worldwide, especially in developing countries. Most deaths occur in young children. Since many countries with malaria are already among the poorer nations, the disease maintains a vicious cycle of disease and poverty.

Where does malaria occur?

Malaria typically is found in warmer regions of the world -- in tropical and subtropical countries. Higher temperatures allow the Anopheles mosquito to thrive. Malaria parasites, which grow and develop inside the mosquito, need warmth to complete their growth before they are mature enough to be transmitted to humans.


How is malaria transmitted?

Usually, people get malaria by being bitten by an infected female Anopheles mosquito. Only Anopheles mosquitoes can transmit malaria and they must have been infected through a previous blood meal taken on an infected person.
When a mosquito bites, a small amount of blood is taken in which contains the microscopic malaria parasites. The parasite grows and matures in the mosquito's gut for a week or more, then travels to the mosquito's salivary glands. When the mosquito next takes a blood meal, these parasites mix with the saliva and are injected into the bite.
Once in the blood, the parasites travel to the liver and enter liver cells to grow and multiply. During this "incubation period", the infected person has no symptoms. After as few as 8 days or as long as several months, the parasites leave the liver cells and enter red blood cells. Once in the cells, they continue to grow and multiply. After they mature, the infected red blood cells rupture, freeing the parasites to attack and enter other red blood cells. Toxins released when the red cells burst are what cause the typical fever, chills, and flu-like malaria symptoms.
If a mosquito bites this infected person and ingests certain types of malaria parasites ("gametocytes"), the cycle of transmission continues.
Because the malaria parasite is found in red blood cells, malaria can also be transmitted through blood transfusion, organ transplant, or the shared use of needles or syringes contaminated with blood. Malaria may also be transmitted from a mother to her fetus before or during delivery ("congenital" malaria).
Malaria is not transmitted from person to person like a cold or the flu. You cannot get malaria from casual contact with malaria-infected people.

Who is at risk for malaria?

Anyone can get malaria. Most cases occur in residents of countries with malaria transmission and travelers to those countries. In non-endemic countries, cases can occur in non-travelers as congenital malaria, introduced malaria, or transfusion malaria (see above).


If I live in an area where malaria is a problem, how can I prevent myself and my family from getting sick?

You and your family can prevent malaria by

  • keeping mosquitoes from biting you, especially at night.
  • taking antimalarial drugs to kill the parasites.
  • eliminating places around your home where mosquitoes breed.
  • spraying insecticides on your home's walls to kill adult mosquitoes that come inside.
  • sleeping under bed nets - especially effective if they have been treated with insecticide, and wearing insect repellent and long-sleeved clothing if out of doors at night.

What are the signs and symptoms of malaria?

Symptoms of malaria include fever and flu-like illness, including shaking chills, headache, muscle aches, and tiredness. Nausea, vomiting, and diarrhea may also occur. Malaria may cause anemia and jaundice (yellow coloring of the skin and eyes) because of the loss of red blood cells. Infection with one type of malaria, Plasmodium falciparum, if not promptly treated, may cause kidney failure, seizures, mental confusion, coma, and death.

How soon will a person feel sick after being bitten by an infected mosquito?

For most people, symptoms begin 10 days to 4 weeks after infection, although a person may feel ill as early as 7 days or as late as 1 year later. Two kinds of malaria, P. vivax and P. ovale, can relapse. In P. vivax and P. ovale infections, some parasites can remain dormant in the liver for several months up to about 4 years after a person is bitten by an infected mosquito. When these parasites come out of hibernation and begin invading red blood cells ("relapse"), the person will become sick.

How do I know if I have malaria?

Most people, at the beginning of the disease, have fever, sweats, chills, headaches, malaise, muscles aches, nausea and vomiting. Malaria can very rapidly become a severe and life-threatening disease. The surest way for you and your doctor to know whether you have malaria is to have a diagnostic test where a drop of your blood is examined under the microscope for the presence of malaria parasites.
If you are sick and there is any suspicion of malaria (for example, if you have recently traveled in a malaria-risk area) the test should be performed without delay.

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Dengue


What is dengue?

Dengue (pronounced den' gee) is a disease caused by any one of four closely related viruses (DEN-1, DEN-2, DEN-3, or DEN-4). The viruses are transmitted to humans by the bite of an infected mosquito. In the Western Hemisphere, the Aedes aegypti mosquito is the most important transmitter or vector of dengue viruses.


What is dengue haemorrhagic fever (DHF)?

DHF is a more severe form of dengue. It can be fatal if unrecognised and not properly treated. DHF is caused by infection with the same viruses that cause dengue. With good medical management, mortality due to DHF can be less than 1%.


How are dengue and dengue hemorrhagic fever (DHF) spread?

Dengue is transmitted to people by the bite of an Aedes mosquito that is infected with a dengue virus. The mosquito becomes infected with dengue virus when it bites a person who has dengue or DHF and after about a week can transmit the virus while biting a healthy person. Dengue cannot be spread directly from person to person.


What are the symptoms of the disease?

The principal symptoms of dengue are high fever, severe headache, backache, joint pains, nausea and vomiting, eye pain, and rash. Generally, younger children have a milder illness than older children and adults.
Dengue hemorrhagic fever is characterized by a fever that lasts from 2 to 7 days, with general signs and symptoms that could occur with many other illnesses (e.g., nausea, vomiting, abdominal pain, and headache). This stage is followed by hemorrhagic manifestations, tendency to bruise easily or other types of skin haemorrhages, bleeding nose or gums, and possibly internal bleeding. The smallest blood vessels (capillaries) become excessively permeable ("leaky"), allowing the fluid component to escape from the blood vessels. This may lead to failure of the circulatory system and shock, followed by death, if circulatory failure is not corrected.


What is the treatment for dengue?

There is no specific medication for treatment of a dengue infection. Persons who think they have dengue should use analgesics (pain relievers) with acetaminophen and avoid those containing aspirin. They should also rest, drink plenty of fluids, and consult a physician.


Is there an effective treatment for dengue hemorrhagic fever (DHF)?

As with dengue, there is no specific medication for DHF. It can however be effectively treated by fluid replacement therapy if an early clinical diagnosis is made. Hospitalisation is frequently required in order to adequately manage DHF.


What can be done to reduce the risk of acquiring dengue?

There is no vaccine for preventing dengue. The best preventive measure for residents living in areas infested with Aedes aegypti is to eliminate the places where the mosquito lays her eggs, primarily artificial containers that hold water.
Items that collect rainwater or are used to store water (for example, plastic containers, big drums, buckets, or used automobile tires) should be covered or properly discarded. Pet and animal watering containers and vases with fresh flowers should be emptied and scoured at least once a week. This will eliminate the mosquito eggs and larvae and reduce the number of mosquitoes present in these areas.

  • Tests for Dengue.
  • CBC - WBC Count, Platelet Count, Haematocrit.
  • S. Protien, S. Albumin.
  • Liver Function Tests.
  • Urine - microscopic haematuria.
  • Dengue IgG & IgM.
The tests for diagnosis of dengue infection are time dependent.
If the patient presents within the first 5 days after onset of symptoms, which is the acute phase of the illness, a blood sample should be drawn immediately, to be tested for virus isolation. Virus can be isolated most easily in samples drawn in the first days after onset of symptoms, although it has been isolated as long as 12 days after onset.
A convalescent-phase sample should also be drawn to test for IgM antibody. This sample should be drawn between 6 and 21 days after symptom onset.
If the patient presents six or more days after symptom onset, the blood sample should be drawn as soon as possible. This sample should then be tested for serum IgM antibody.

Diabetes

 

Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. The cause of diabetes continues to be a mystery, although both genetics and environmental factors such as obesity and lack of exercise appear to play roles.

In order to determine whether or not a patient has pre-diabetes or diabetes, we conduct a Fasting Blood Glucose Test (FBG) or an Oral Glucose Tolerance Test (OGTT). Either test can be used to diagnose pre-diabetes or diabetes. The American Diabetes Association recommends the FPG because it is easier, faster, and less expensive to perform.

With the FPG test, a fasting blood glucose level between 100 and 125 mg/dl signals pre-diabetes. A person with a fasting blood glucose level of 126 mg/dl or higher has diabetes.

In the OGTT test, a person's blood glucose level is measured after a fast and two hours after drinking a glucose-rich beverage. If the two-hour blood glucose level is between 140 and 199 mg/dl, the person tested has pre-diabetes. If the two-hour blood glucose level is at 200 mg/dl or higher, the person tested has diabetes.


Major Types of Diabetes

  1. Type 1 Diabetes : Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. In type 1diabetes, the body does not produce insulin.
  2. Type 2 Diabetes : Type 2 diabetes is the most common form of diabetes. In type 2 diabetes, either the body does not produce enough insulin or the cells ignore the insulin. When glucose builds up in the blood instead of going into cells, it can cause two problems:


    * Right away, your cells may be starved for energy.
    * Over time, high blood glucose levels may hurt your eyes, kidneys, nerves or heart.


    Finding out you have diabetes is scary. But don't panic. Having diabetes is serious, but people with diabetes can live long, healthy, happy lives.

  3. Gestational Diabetes : Pregnant women who have never had diabetes before but who have high blood sugar (glucose) levels during pregnancy are said to have gestational diabetes.

    Gestational diabetes starts when your body is not able to make and use all the insulin it needs for pregnancy. Without enough insulin, glucose cannot leave the blood and be changed to energy. Glucose builds up in the blood to high levels. This is called hyperglycemia.

  4. Pre Diabetes : Before people develop type 2 diabetes, they almost always have "pre-diabetes" -- blood glucose levels that are higher than normal but not yet high enough to be diagnosed as diabetes. Recent research has shown that some long-term damage to the body, especially the heart and circulatory system, may already be occurring during pre-diabetes.

    Research has also shown that if you take action to manage your blood glucose when you have pre-diabetes, you can delay or prevent type 2 diabetes from ever developing.


How to Tell if You Have Pre-Diabetes


While diabetes and pre-diabetes occur in people of all ages and races, some groups have a higher risk for developing the disease than others. There are two different tests your doctor can use to determine whether you have pre-diabetes: the fasting blood glucose test (FPG) or the oral glucose tolerance test (OGTT). The blood glucose levels measured after these tests determine whether you have a normal metabolism, or whether you have pre-diabetes or diabetes. If your blood glucose level is abnormal following the FPG, you have impaired fasting glucose (IFG); if your blood glucose level is abnormal following the OGTT, you have impaired glucose tolerance (IGT).


Does Someone You Know Have Pre-diabetes?

Mr. Shah, 48, was getting dangerously close to a diagnosis of type 2 diabetes. A fasting blood glucose done by his doctor was 111 mg/dl, and a week later it was 115 mg/dl. Normal fasting blood glucose is under 100 mg/dl; diabetes is diagnosed when the fasting blood glucose is 126 mg/dl or higher. A fasting blood glucose between 100 mg/dl and 125 mg/dl is called impaired fasting glucose (IFG).

His doctor sent Mr. Shah for a glucose tolerance check. Mr. Shah drank a set amount of glucose; his blood glucose two hours later was 173mg/dl. Normal is under 140mg/dl, diabetes is 200 mg/dl or over. Mr. Shah had impaired glucose tolerance (IGT).

Because so many people with IFG or IGT go on to develop diabetes, IFG and IGT are called pre-diabetes.

Would Mr. Shah be one of those who gets worse and develops diabetes? Or would he be able to shift his blood glucose back to solidly non- diabetic levels?

Pre-diabetes was not Mr. Shah's only problem. He had been treated for high blood pressure for eight years. He was overweight, and he had gained 20 pounds in the last year. He was not physically active. He didn't have healthy cholesterol levels. He had a family history of type 2 diabetes and coronary artery disease. All of these taken together meant that Mr. Shah was at high risk of developing type 2 diabetes and having heart problems in the future.


Reversible

Many people with pre-diabetes are able to change their fates by losing a little weight (just 10 or 20 pounds can make a difference) and walking 150 minutes a week. Losing a little weight and being more active also improves blood pressure and cholesterol levels and lowers the risk of heart attack and stroke.
Mr. Shah met with a dietitian for help in losing weight. He had a treadmill stress test to see whether his heart could tolerate an exercise program. He was advised to do 30 minutes of brisk walking five days per week.
Six months later, Mr. Shah returned for a check-up. He had gained seven pounds. He was exercising only 20 minutes per week. His fasting blood glucose had increased to 117 mg/dl.

What You Can Do


First, calculate your body mass index (BMI): Take your weight in pounds, divide by height in inches, divide by height again, then multiply by 703.

Have your blood glucose levels checked if you are:
  • Age 45 or older, especially if your BMI is 25 or higher
  • Under age 45 but your BMI is 25 or higher plus you have another risk factor for type 2 diabetes: high blood pressure, history of gestational diabetes, a baby weighing more than nine pounds at birth, polycystic ovary syndrome, HDL (good) cholesterol under 35 mg/dl, triglycerides over 250 mg/dl, first-degree relative with diabetes, history of vascular disease, or habitual inactivity.

Get rechecked every three years

If blood tests determine that you have pre-diabetes:
  • Ask your doctor for exercise recommendations (Walking is an excellent exercise for most people and has proven effective in reversing pre-diabetes)
  • Redouble your efforts to lose a little weight
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Cholesterol

What Is Cholesterol?

To understand high blood cholesterol, it is important to know more about cholesterol.
Cholesterol is a waxy, fat-like substance that is found in all cells of the body. Your body needs some cholesterol to work the right way and makes all the cholesterol you need.

Cholesterol is also found in some of the foods you eat.

You use cholesterol to make hormones, Vitamin D, and substances that help you digest foods.

Blood is watery and cholesterol is fatty. Just like oil and water, the two do not mix. So, in order to travel in the bloodstream, cholesterol is carried in small packages called lipoproteins (lip-o-PRO-teens). The small packages are made of fat (lipid) on the inside and proteins on the outside. Two kinds of lipoproteins carry cholesterol throughout your body. It is important to have healthy levels of both:

LDL (low density lipoprotein) cholesterol is sometimes called "bad" cholesterol.
High LDL cholesterol leads to a buildup of cholesterol in arteries. The higher the LDL level in your blood, the greater chance you have for getting heart disease.

HDL (high density lipoprotein) cholesterol is sometimes called "good" cholesterol.
HDL carries cholesterol from other parts of your body back to your liver. The liver removes the cholesterol from your body. The higher your HDL cholesterol level, the lower your chance of getting heart disease.

What is a lipid profile?

The lipid profile is a group of tests that are often ordered together to determine risk of coronary heart disease. The tests that make up a lipid profile are tests that have been shown to be good indicators of whether someone is likely to have a heart attack or stroke caused by blockage of blood vessels (hardening of the arteries)


What tests are included in a lipid profile?

The lipid profile includes total cholesterol, HDL-cholesterol (often called good cholesterol), LDL-cholesterol (often called bad cholesterol), and triglycerides.

Sometimes the report will include additional calculated values such as HDL/Cholesterol ratio or a risk score based on lipid profile results, age, sex, and other risk factors.


How is a lipid profile used?

The lipid profile is used to guide physicians in deciding how a person at risk should be treated. The results of the lipid profile are considered along with other known risk factors of heart disease to develop a plan of treatment and follow-up.


What Is High Blood Cholesterol?

Too much cholesterol (ko-LES-ter-ol) in the blood, or high blood cholesterol, can be serious. People with high blood cholesterol have a greater chance of getting heart disease. High blood cholesterol itself does not cause symptoms, so many people are unaware that their cholesterol level is too high.

Other Names for High Blood Cholesterol

  • Hypercholesterolemia
  • Hyperlipidemia.

What Causes High Blood Cholesterol?

A variety of things can affect the cholesterol levels in your blood. Some of these things you can control and others you cannot.


You can control:
What you eat. Certain foods have types of fat that raise your cholesterol level.
Saturated fat raises your LDL cholesterol level more than anything else in your diet.
Trans fatty acids (trans fats) are made when vegetable oil is "hydrogenated" to harden it. Trans fatty acids also raise cholesterol levels.
Cholesterol is found in foods that come from animal sources, for example, egg yolks, meat, and cheese.

Your weight : Being overweight tends to increase your LDL level, lower your HDL level, and increase your total cholesterol level.

Your activity : Lack of regular exercise can lead to weight gain and raise your LDL cholesterol level. Regular exercise can help you lose weight and lower your LDL level. It can also help you raise your HDL level.

You cannot control : Heredity. High blood cholesterol can run in families. An inherited genetic condition (familial hypercholesterolemia) results in very high LDL cholesterol levels. It begins at birth, and results in a heart attack at an early age.

Age and sex Starting at puberty, men have lower levels of HDL than women. As women and men get older, their LDL cholesterol levels rise. Younger women have lower LDL cholesterol levels than men, but after age 55 they have higher levels than men.

What Are the Signs and Symptoms of High Blood Cholesterol?
There are usually no signs or symptoms of high blood cholesterol. Many people don't know that their cholesterol level is too high.

Everyone age 20 and older should have their cholesterol levels checked at least once every 5 years. You and your doctor can discuss how often you should be tested.


How is High Blood Cholesterol Diagnosed?
High blood cholesterol is diagnosed by checking levels of cholesterol in your blood. It is best to have a blood test called a lipid profile to measure your cholesterol levels. Most people will need to "fast" (not eat or drink anything) for 9 to 12 hours before taking the test.

The lipoprotein profile will give information about your:

  • Total cholesterol.
  • LDL (bad) cholesterol: the main source of cholesterol buildup and blockage in the arteries.
  • HDL (good) cholesterol: the good cholesterol that helps keep cholesterol from building up in arteries.
  • Triglycerides: another form of fat in your blood.
If it is not possible to get a lipid profile done, knowing your total cholesterol and HDL cholesterol can give you a general idea about your cholesterol levels. Testing for total and HDL cholesterol does not require fasting. If your total cholesterol is 200 mg/dL or more, or if your HDL is less than 40 mg/dL, you will need to have a lipoprotein profile done.
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Leptospirosis

What is leptospirosis?
Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira.

In humans it causes a wide range of symptoms, and some infected persons may have no symptoms at all.

Symptoms of leptospirosis include high fever, severe headache, chills, muscle aches, and vomiting, and may include jaundice (yellow skin and eyes), red eyes, abdominal pain, diarrhea, or a rash. If the disease is not treated, the patient could develop kidney damage, meningitis (inflammation of the membrane around the brain and spinal cord), liver failure, and respiratory distress. In rare cases death occurs.

Many of these symptoms can be mistaken for other diseases. Leptospirosis is confirmed by laboratory testing of a blood or urine sample.


How do people get leptospirosis?
Outbreaks of leptospirosis are usually caused by exposure to water contaminated with the urine of infected animals. Many different kinds of animals carry the bacterium; they may become sick but sometimes have no symptoms.

Leptospira organisms have been found in cattle, pigs, horses, dogs, rodents, and wild animals. Humans become infected through contact with water, food, or soil containing urine from these infected animals. This may happen by swallowing contaminated food or water or through skin contact, especially with mucosal surfaces, such as the eyes or nose, or with broken skin.

The disease is not known to be spread from person to person.


How long is it between the time of exposure and when people become sick?
The time between a person's exposure to a contaminated source and becoming sick is 2 days to 4 weeks. Illness usually begins abruptly with fever and other symptoms.

Leptospirosis may occur in two phases; after the first phase, with fever, chills, headache, muscle aches, vomiting, or diarrhea, the patient may recover for a time but become ill again. If a second phase occurs, it is more severe; the person may have kidney or liver failure or meningitis. This phase is also called Weil's disease.
The illness lasts from a few days to 3 weeks or longer. Without treatment, recovery may take several months.


Where is leptospirosis found?
Leptospirosis occurs worldwide but is most common in temperate or tropical climates. It is an occupational hazard for many people who work outdoors or with animals, for example, farmers, sewer workers, veterinarians, fish workers, dairy farmers, or military personnel. It is a recreational hazard for campers or those who participate in outdoor sports in contaminated areas and has been associated with swimming, wading, and whitewater rafting in contaminated lakes and rivers. The incidence is also increasing among urban children.

How is leptospirosis treated?
Leptospirosis is treated with antibiotics, such as doxycycline or penicillin, which should be given early in the course of the disease. Intravenous antibiotics may be required for persons with more severe symptoms.

Persons with symptoms suggestive of leptospirosis should contact a physician.


Can leptospirosis be prevented?
The risk of acquiring leptospirosis can be greatly reduced by not swimming or wading in water that might be contaminated with animal urine.

Protective clothing or footwear should be worn by those exposed to contaminated water or soil because of their job or recreational activities.

Tests for Leptospirosis


  • Complete Blood Count
  • Urinalysis
  • Creatinine
  • Dark Ground Illumination
  • Leptospirosis IgM Spot Test

Tuberculosis

What is Tuberculosis (TB)?
Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs. But, TB bacteria can attack any part of the body such as the kidney, spine, and brain. If not treated properly, TB disease can be fatal.
TB is spread through the air from one person to another. The bacteria are put into the air when a person with active TB disease of the lungs or throat coughs or sneezes. People nearby may breathe in these bacteria and become infected.
However, not everyone infected with TB bacteria becomes sick.
People who are not sick have what is called latent TB infection. People who have latent TB infection do not feel sick, do not have any symptoms, and cannot spread TB to others. But, some people with latent TB infection go on to get TB disease.
People with active TB disease can be treated and cured if they seek medical help. Even better, people with latent TB infection can take medicine so that they will not develop active TB disease.

How is TB spread?
TB is spread through the air from one person to another. The bacteria are put into the air when a person with active TB disease of the lungs or throat coughs or sneezes. People nearby may breathe in these bacteria and become infected.
When a person breathes in TB bacteria, the bacteria can settle in the lungs and begin to grow. From there, they can move through the blood to other parts of the body, such as the kidney, spine, and brain.
TB in the lungs or throat can be infectious. This means that the bacteria can be spread to other people. TB in other parts of the body, such as the kidney or spine, is usually not infectious.
People with active TB disease are most likely to spread it to people they spend time with every day. This includes family members, friends, and coworkers.

What is latent TB infection?
In most people who breathe in TB bacteria and become infected, the body is able to fight the bacteria to stop them from growing. The bacteria become inactive, but they remain alive in the body and can become active later. This is called latent TB infection. People with latent TB infection

  • have no symptoms
  • don't feel sick
  • can't spread TB to others
  • usually have a positive skin test reaction
  • can develop active TB disease if they do not receive treatment for latent TB infection

Many people who have latent TB infection never develop active TB disease. In these people, the TB bacteria remain inactive for a lifetime without causing disease. But in other people, especially people who have weak immune systems, the bacteria become active and cause TB disease.

What is active TB disease?

TB bacteria become active if the immune system can't stop them from growing. The active bacteria begin to multiply in the body and cause active TB disease. The bacteria attack the body and destroy tissue. If this occurs in the lungs, the bacteria can actually create a hole in the lung. Some people develop active TB disease soon after becoming infected, before their immune system can fight the TB bacteria. Other people may get sick later, when their immune system becomes weak for another reason.
Babies and young children often have weak immune systems. People infected with HIV, the virus that causes AIDS, have very weak immune systems. Other people can have weak immune systems, too, especially people with any of these conditions:


  • substance abuse
  • diabetes mellitus
  • silicosis
  • cancer of the head or neck
  • leukemia or Hodgkin's disease
  • severe kidney disease
  • low body weight
  • certain medical treatments (such as corticosteroid treatment or organ transplants)
  • specialized treatment for rheumatoid arthritis or Crohn's disease

Symptoms of TB depend on where in the body the TB bacteria are growing. TB bacteria usually grow in the lungs. TB in the lungs may cause symptoms such as

  • a bad cough that lasts 3 weeks or longer
  • pain in the chest
  • coughing up blood or sputum (phlegm from deep inside the lungs)
Other symptoms of active TB disease are

  • weakness or fatigue
  • weight loss
  • no appetite
  • chills
  • fever
  • sweating at night

The TB skin test

The TB skin test may be used to find out if you have TB infection. You can get a skin test at any pathology laboratory. A technician will inject a small amount of testing fluid (called tuberculin or PPD) just under the skin on the under side of the forearm. After 48 hours, you must return to have your skin test read by the laboratory technician. You may have a swelling where the tuberculin was injected. The technician will measure this swelling and tell you if your reaction to the test is positive or negative. A positive reaction usually means that you have been infected by someone with active TB disease.
If you have recently spent time with and been exposed to someone with active TB disease, your TB skin test reaction may not be positive yet. You may need a second skin test 8 to 10 weeks after the last time you spent time with the person. This is because it can take several weeks after infection for your immune system to react to the TB skin test. If your reaction to the second test is negative, you probably do not have latent TB infection.

QuantiFERON®-TB Gold

QuantiFERON®-TB Gold (QFT) is a blood test used to find out if you are infected with TB bacteria. The QFT measures the response to TB proteins when they are mixed with a small amount of blood. Currently, few labs offer the QFT. If your laboratory does offer the QFT, only one visit is required, at which time your blood is drawn for the test.

What if I have a positive test for TB?
If you have a positive reaction to the TB skin test or the QFT, your doctor may do other tests to see if you have active TB disease. These tests usually include a chest x-ray and a test of the phlegm you cough up. Because the TB bacteria may be found somewhere other than your lungs, your doctor may check your blood or urine, or do other tests. If you have active TB disease, you will need to take medicine to cure the disease.

Tuberculosis (TB) Profile


  • Complete Blood Count
  • ESR
  • Adenosine Deaminase
  • Mantoux Test
  • Chest X Ray
  • Sputum AFB

Arthritis


While often referred to as if it were a single disease, arthritis is actually an umbrella term used for a group of more than 100 medical conditions that collectively affect nearly 70 million adults and 300,000 children in America alone.

While the most common form of arthritis - osteoarthritis - is most prevalent in people over 60, arthritis in its various forms can start as early as infancy. Some forms affect people in their young-adult years as they are beginning careers and families and still others start during the peak career and child-rearing years.
The common thread among these 100-plus conditions is that they all affect the musculoskeletal system and specifically the joints - where two or more bones meet.
Arthritis-related joint problems include pain, stiffness, inflammation and damage to joint cartilage (the tough, smooth tissue that covers the ends of the bones, enabling them to glide against one another) and surrounding structures. Such damage can lead to joint weakness, instability and visible deformities that, depending on the location of joint involvement, can interfere with the most basic daily tasks such as walking, climbing stairs, using a computer keyboard, cutting your food or brushing your teeth.
For many people with arthritis, however, joint involvement is not the extent of the problem. Many forms of arthritis are classified as systemic, meaning they can affect the whole body. In these diseases, arthritis can cause damage to virtually any bodily organ or system, including the heart, lungs, kidneys, blood vessels and skin. Arthritis-related conditions primarily affect the muscles and the bones.

Arthritis causes pain, loss of movement and sometimes swelling. Some types of arthritis are:

  • Osteoarthritis, a degenerative joint disease in which the cartilage that covers the ends of bones in the joint deteriorates, causing pain and loss of movement as bone begins to rub against bone. It is the most prevalent form of arthritis.
  • Rheumatoid arthritis, an autoimmune disease in which the joint lining becomes inflamed as part of the body's immune system activity. Rheumatoid arthritis is one of the most serious and disabling types, affecting mostly women.
  • Gout, which affects mostly men. It is usually the result of a defect in body chemistry. This painful condition most often attacks small joints, especially the big toe. Fortunately, gout almost always can be completely controlled with medication and changes in diet.
  • Ankylosing spondylitis, a type of arthritis that affects the spine. As a result of inflammation, the bones of the spine grow together.
  • Juvenile arthritis, a general term for all types of arthritis that occur in children. Children may develop juvenile rheumatoid arthritis or childhood forms of lupus, ankylosing spondylitis or other types of arthritis.
  • Systemic lupus erythematosus (lupus), a serious disorder that can inflame and damage joints and other connective tissues throughout the body.
  • Scleroderma, a disease of the body's connective tissue that causes a thickening and hardening of the skin.

Fibromyalgia, in which widespread pain affects the muscles and attachments to the bone. It affects mostly women.

Arthritis Profile

  • Complete Blood Count
  • ESR
  • R A Factor
  • Uric Acid
  • C Reactive Protein (Quantitative)
  • Anti Nuclear Antibody
  • Creatinine
  • Urinalysis

Anaemia

Anemia is a serious condition that can make a person feel tired and weak and can lead to serious heart problems and other health complications.
The good news is anemia can be treated and people may regain their independence and go on to live healthier, more productive lives.
The blood in our bodies is composed of three types of cells (red blood cells, white blood cells and platelets) that circulate throughout the body.
Red blood cells contain hemoglobin (Hb), a red, iron-rich protein that carries oxygen from the lungs to all of the body's muscles and organs. Oxygen provides the energy the body needs for all of its normal activities. Anemia occurs when the number of red blood cells (or the Hb in them) falls below normal and the body gets less oxygen and therefore has less energy than it needs to function properly.
Anemia may become worse if it is not treated, and it can lead to potentially serious, even life-threatening complications. When the number of red blood cells decreases, the heart works harder, pumping more blood to send more oxygen throughout the body. If the heart works too hard, it can develop a rapid heartbeat (tachycardia), and/or another serious condition known as left ventricular hypertrophy (LVH), an enlargement of the heart muscle that in turn can lead to heart failure.

What causes Anaemia?

Anemia occurs when the body produces too few red blood cells, loses too many of them, or if red blood cells are destroyed faster than they can be replaced.

There are close to 100 different types of anemia with many causes, including:

  • Serious disease
  • Vitamin or iron deficiencies
  • Blood loss
  • Genetic or acquired defects or disease
  • Side effects of medication
Who is at risk?
Evidence shows that people who suffer from the following serious diseases are at greatest risk of developing anemia:

  • Chronic Kidney Disease (CKD)
  • Diabetes
  • Cancer
  • Heart Disease
  • Rheumatoid Arthritis (RA)
  • Inflammatory Bowel Disease (IBD)
Also at risk are:

  • People over the age of 65
  • People with HIV/AIDS
  • Patients undergoing surgery
  • Signs and Symptoms

Anemia can be difficult to identify because early symptoms may be mild. In addition, it is easy to mistake some symptoms of anemia for symptoms of serious disease or medication side effects. As symptoms of anemia worsen, however, they can significantly affect a person's quality of life.
It is common for people to ignore symptoms of anaemia or attribute them to other causes. Anemia can make it hard to find the energy to enjoy hobbies or other leisure activities, or even to complete basic tasks at home or at work. Particularly for a person with a serious disease, the fatigue, weakness and other symptoms associated with anemia can compound the challenges of coping with the serious disease.
Major symptoms of anemia include:

  • Extreme fatigue
  • Weakness
  • Shortness of breath
  • Confusion or loss of concentration
  • Dizziness or fainting
  • Pale skin, including decreased pinkness of the lips, gums, lining of the eyelids, nail beds and palms
  • Rapid heart beat (tachycardia)
  • Feeling cold
  • Sadness or depression

Because the symptoms of anemia are easily confused with the symptoms of other conditions, it is important to see a doctor for an evaluation if you are experiencing significant fatigue or other signs and symptoms listed above, or if you already have a serious disease.

Diagnosing Anaemia

Doctors diagnose anemia with the help of a medical history, physical exam and blood tests, including a complete blood count (CBC) to measure levels of red blood cells and hemoglobin in the blood.

On average, a normal hemoglobin range should be between 12 and 18 g/dL (grams per deciliter of blood).
Anemia occurs when the number of red blood cells (or the hemoglobin in them) falls below these normal ranges and the body's organs and tissues receive less oxygen than needed to function properly. Although "normal" is something that varies from person to person, if your numbers are below the ranges, then you may be feeling worse than you should.


Treating Anaemia

The treatment of anemia varies greatly depending on the type. Your physician will help you determine the best treatment options, such as diet modification, or nutritional supplements, or medication, if needed.
Treatment for anemia associated with serious diseases tends to focus first on addressing the underlying disease. But if anemia persists or symptoms worsen, treatment may reduce the risk of severe, possibly life-threatening complications and improve quality of life.

Anaemia Profile


  • Complete Blood Count
  • Iron
  • Total Iron Binding Capacity (TIBC)
  • Iron Saturation
  • Ferritin
  • Reticulocyte Count
Do you need to be screened for anaemia?

Call +91 288 2770646 or write to info@shreylab.com for more details.



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