Cholesterol

What Is Cholesterol?

To understand high blood cholesterol, it is important to know more about cholesterol.
Cholesterol is a waxy, fat-like substance that is found in all cells of the body. Your body needs some cholesterol to work the right way and makes all the cholesterol you need.

Cholesterol is also found in some of the foods you eat.

You use cholesterol to make hormones, Vitamin D, and substances that help you digest foods.

Blood is watery and cholesterol is fatty. Just like oil and water, the two do not mix. So, in order to travel in the bloodstream, cholesterol is carried in small packages called lipoproteins (lip-o-PRO-teens). The small packages are made of fat (lipid) on the inside and proteins on the outside. Two kinds of lipoproteins carry cholesterol throughout your body. It is important to have healthy levels of both:

LDL (low density lipoprotein) cholesterol is sometimes called "bad" cholesterol.
High LDL cholesterol leads to a buildup of cholesterol in arteries. The higher the LDL level in your blood, the greater chance you have for getting heart disease.
HDL (high density lipoprotein) cholesterol is sometimes called "good" cholesterol.
HDL carries cholesterol from other parts of your body back to your liver. The liver removes the cholesterol from your body. The higher your HDL cholesterol level, the lower your chance of getting heart disease.

What is a lipid profile?

The lipid profile is a group of tests that are often ordered together to determine risk of coronary heart disease. The tests that make up a lipid profile are tests that have been shown to be good indicators of whether someone is likely to have a heart attack or stroke caused by blockage of blood vessels (hardening of the arteries)


What tests are included in a lipid profile?

The lipid profile includes total cholesterol, HDL-cholesterol (often called good cholesterol), LDL-cholesterol (often called bad cholesterol), and triglycerides.

Sometimes the report will include additional calculated values such as HDL/Cholesterol ratio or a risk score based on lipid profile results, age, sex, and other risk factors.


How is a lipid profile used?

The lipid profile is used to guide physicians in deciding how a person at risk should be treated. The results of the lipid profile are considered along with other known risk factors of heart disease to develop a plan of treatment and follow-up.


What Is High Blood Cholesterol?

Too much cholesterol (ko-LES-ter-ol) in the blood, or high blood cholesterol, can be serious. People with high blood cholesterol have a greater chance of getting heart disease. High blood cholesterol itself does not cause symptoms, so many people are unaware that their cholesterol level is too high.

Other Names for High Blood Cholesterol

  • Hypercholesterolemia
  • Hyperlipidemia.

What Causes High Blood Cholesterol?

A variety of things can affect the cholesterol levels in your blood. Some of these things you can control and others you cannot.


You can control:
What you eat. Certain foods have types of fat that raise your cholesterol level.
Saturated fat raises your LDL cholesterol level more than anything else in your diet.
Trans fatty acids (trans fats) are made when vegetable oil is "hydrogenated" to harden it. Trans fatty acids also raise cholesterol levels.
Cholesterol is found in foods that come from animal sources, for example, egg yolks, meat, and cheese.

Your weight : Being overweight tends to increase your LDL level, lower your HDL level, and increase your total cholesterol level.

Your activity : Lack of regular exercise can lead to weight gain and raise your LDL cholesterol level. Regular exercise can help you lose weight and lower your LDL level. It can also help you raise your HDL level.

You cannot control : Heredity. High blood cholesterol can run in families. An inherited genetic condition (familial hypercholesterolemia) results in very high LDL cholesterol levels. It begins at birth, and results in a heart attack at an early age.

Age and sex Starting at puberty, men have lower levels of HDL than women. As women and men get older, their LDL cholesterol levels rise. Younger women have lower LDL cholesterol levels than men, but after age 55 they have higher levels than men.

What Are the Signs and Symptoms of High Blood Cholesterol?
There are usually no signs or symptoms of high blood cholesterol. Many people don't know that their cholesterol level is too high.

Everyone age 20 and older should have their cholesterol levels checked at least once every 5 years. You and your doctor can discuss how often you should be tested.


How is High Blood Cholesterol Diagnosed?
High blood cholesterol is diagnosed by checking levels of cholesterol in your blood. It is best to have a blood test called a lipid profile to measure your cholesterol levels. Most people will need to "fast" (not eat or drink anything) for 9 to 12 hours before taking the test.

The lipoprotein profile will give information about your:

  • Total cholesterol.
  • LDL (bad) cholesterol: the main source of cholesterol buildup and blockage in the arteries.
  • HDL (good) cholesterol: the good cholesterol that helps keep cholesterol from building up in arteries.
  • Triglycerides: another form of fat in your blood.
If it is not possible to get a lipid profile done, knowing your total cholesterol and HDL cholesterol can give you a general idea about your cholesterol levels. Testing for total and HDL cholesterol does not require fasting. If your total cholesterol is 200 mg/dL or more, or if your HDL is less than 40 mg/dL, you will need to have a lipoprotein profile done.


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